IV Vitamin C Dosage to Avoid Renal Stones

Dosing Recommendations

The American Society of Parenteral and Enteral Nutrition recommends daily IV vitamin C should be 100-200 mg/day for routine parenteral nutrition in adults without critical illness 3
The European Society for Clinical Nutrition and Metabolism recommends pediatric dosing: 15-25 mg/kg/day for infants, 80 mg/day for older children 4
High-dose IV vitamin C (2-3 g/day) can be administered during acute critical illness for 4-7 days without significant stone risk due to the short duration, according to the Society of Critical Care Medicine 3

The National Kidney Foundation states that vitamin C is metabolized to oxalate, which increases urinary oxalate excretion and calcium oxalate supersaturation 1, 2, 5
Men consuming ≥1000 mg/day had a 40% higher risk of stone formation compared to those consuming <90 mg/day, as reported by the American Urological Association 1, 2, 5

The American College of Physicians recommends that calcium stone formers with hyperoxaluria should discontinue vitamin C supplements entirely 1, 2, 5

The National Institute of Diabetes and Digestive and Kidney Diseases recommends maintaining fluid intake to achieve urine volume ≥2.5 liters daily 6
The American Society of Nephrology suggests performing 24-hour urine collections to monitor urinary oxalate, calcium, and volume 6
The European Renal Association recommends measuring urinary oxalate excretion; primary hyperoxaluria should be suspected when urinary oxalate exceeds 75 mg/day in adults without bowel dysfunction 6