Fluconazole-Associated Potassium Serum Level Effects

Introduction to Fluconazole Therapy

• The American Academy of Family Physicians recommends reducing fluconazole dose by 50% for patients with creatinine clearance <50 mL/min 3

Renal Considerations in Fluconazole Administration

• The Infectious Diseases Society of America guidelines suggest that fluconazole dosing must be adjusted in patients with creatinine clearance <50 mL/min, with a reduced elimination half-life in patients with severe renal dysfunction 1, 2

Dosing Adjustments for Fluconazole

• The National Kidney Foundation recommends that hemodialysis patients require supplemental fluconazole dosing post-dialysis, as hemodialysis removes approximately 38% of fluconazole over 3 hours 3