Weight Loss in Marijuana Users

Clinical Considerations

Cannabis withdrawal syndrome can include decreased appetite as a symptom, which may contribute to weight loss in periods of abstinence, according to Praxis Medical Insights 1
The severity of withdrawal symptoms correlates with the amount of cannabis used before cessation, with heavier users more likely to experience appetite changes, as reported by Praxis Medical Insights 1
In cancer patients, dronabinol (synthetic THC) has been studied for treating anorexia and weight loss, but evidence is inconsistent regarding its effectiveness, as noted in Clinical Nutrition 2, 3, 4
Clinical trials in cancer patients have shown mixed results regarding THC's ability to improve appetite and weight, with some studies showing benefit and others showing no improvement compared to placebo, according to Clinical Nutrition 3 and the Journal of the National Comprehensive Cancer Network 5

Regular cannabis use carries risks including cannabis use disorder (affecting approximately 10% of users), psychiatric effects, and potential cardiovascular side effects, as reported in the Journal of Clinical Oncology 6
Cannabis hyperemesis syndrome, characterized by cyclic vomiting episodes, can occur with high-dose cannabis use and may contribute to weight loss in affected individuals, according to the Journal of Clinical Oncology 6
Cannabis withdrawal may exacerbate psychiatric disorders in vulnerable individuals and contribute to increased distress, as noted by Praxis Medical Insights 1