Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/31/2025

Multi-Cancer Early Detection Tests: Current Status and Clinical Utility

Comparison to Traditional Cancer Screening Methods

  • The American Cancer Society recommends colonoscopy as the gold standard for both cancer detection and prevention through polyp removal for colorectal cancer 1, 2, 3
  • Traditional screening tests like mammography for breast cancer, PSA testing for prostate cancer, and Pap tests for cervical cancer remain the recommended approaches for their respective cancer types, as suggested by the American Cancer Society 4, 5

Important Considerations

  • The National Comprehensive Cancer Network notes that false positives from multi-cancer detection tests can lead to unnecessary additional testing and patient anxiety 6