Gastrin Secretion and Diagnostic Considerations

Diagnostic Considerations for Gastrin-Related Conditions

• The European Society of Gastrointestinal Endoscopy recommends that fasting gastrin levels should be measured after an overnight fast to establish baseline values, as part of the evaluation of conditions like Zollinger-Ellison syndrome 1
• The American Gastroenterological Association suggests that PPIs should be withdrawn with great caution and ideally stopped 10 days to 2 weeks before any planned estimation of circulating fasting gastrin, due to the risk of hypergastrinemia 1