Optimal Omeprazole Administration Timing for Cesarean Section

Evidence-Based Considerations

• The American College of Obstetricians and Gynecologists recommends omeprazole 40 mg intravenously at least 60-90 minutes before induction of anesthesia for optimal gastric acid suppression in cesarean section without ranitidine 1
• Omeprazole absorption is pH-independent, and it is readily absorbed in the duodenum and upper jejunum, making standard oral formulations effective in most patients 2

Alternative H2-Antagonist Options

• Famotidine 20 mg IV or nizatidine 150 mg can serve as ranitidine alternatives with similar onset profiles, achieving therapeutic effect within 30-45 minutes, making them suitable for urgent cases 1