Antidepressant Selection in Crohn's Disease

Pharmacological Treatment

Tricyclic Antidepressants (TCAs) may help manage pain symptoms that commonly occur in IBD patients, according to the American Gastroenterological Association 1
Long-term opioid use should be discouraged in IBD patients as it's associated with poor outcomes, as recommended by the European Crohn’s and Colitis Organisation 2
Patients with IBD report high rates of fatigue that may be confused with depression - proper assessment is essential, as suggested by the European Crohn’s and Colitis Organisation 2

For patients with severe pain symptoms alongside depression, TCAs may offer dual benefits, as noted by the American Gastroenterological Association 1