Risk of Complications and Adverse Effects with Esomeprazole

Adverse Event Rates and Tolerability

• The American College of Cardiology is not mentioned, however, esomeprazole at 40 mg twice daily for 16 weeks is well tolerated with adverse event rates comparable to placebo, with the most common side effects being constipation and upper respiratory tract infections occurring in ≥5% of patients 1
• Constipation is the most frequently reported adverse effect 1
• Upper respiratory tract infection occurs commonly 1
• The 20 mg component is equivalent to 20 mg omeprazole once daily in terms of acid suppression 1
• Take 30 minutes before meals for optimal absorption and effectiveness 1
• Long-term use of proton pump inhibitors has been associated with increased risk of cardiovascular disease and morbidity 2
• Common but non-serious effects, such as constipation and URI, occur in ≥5% of patients 1