Chlorhexidine Decolonization Guidelines

Standard Decolonization Protocol

• The Infectious Diseases Society of America recommends applying chlorhexidine body wash daily for 5-14 days in combination with intranasal mupirocin twice daily for 5-10 days 1, 2
• The exact duration within the 5-14 day range is not firmly established by clinical trials, but most protocols use 5-7 days based on ongoing research 1, 2, 3

Alternative Decolonization Methods

• For patients who prefer or require an alternative approach, the Infectious Diseases Society of America suggests using dilute bleach baths (1 teaspoon per gallon of water) for 15 minutes, twice weekly for 3 months 1, 2, 4

Critical Implementation Points

• The Infectious Diseases Society of America indicates that decolonization should only be considered after optimizing wound care and hygiene measures have failed 1
• Decolonization is indicated for recurrent skin and soft tissue infections despite proper wound management 1
• The Infectious Diseases Society of America recommends always combining chlorhexidine with intranasal mupirocin for optimal results 1, 2, 5
• Ensure adequate dilution of all antiseptic agents to prevent skin irritation 2, 3
• Reinforce hygiene measures throughout and after the decolonization period 1, 3