Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/23/2025

Treatment of Common Cold

Evidence Against Steroid Use

  • The American Academy of Otolaryngology recommends against the use of intranasal corticosteroids for symptomatic relief from the common cold, as there is no evidence to support their use 1, 2
  • The American College of Physicians found no benefit of intranasal corticosteroids for duration or severity of common cold symptoms is not a recommended treatment, however first-generation antihistamine/decongestant combinations have shown effectiveness for symptom relief 3
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) can provide relief for headache, malaise, and myalgia associated with the common cold, according to the American College of Chest Physicians 4
  • Zinc administered as zinc acetate or zinc gluconate lozenges at doses ≥75 mg/day taken within 24 hours of symptom onset can significantly reduce the duration of common cold, as stated by the American Academy of Otolaryngology 1
  • Nasal decongestants can reduce symptoms of nasal blockage, though they should only be used short-term, as recommended by the American Academy of Otolaryngology 1
  • Newer-generation, non-sedating antihistamines should not be used as they are ineffective in treating common cold symptoms, according to the American Academy of Family Physicians and the British Thoracic Society 3, 5
  • The benefits of any symptomatic treatments must be weighed against potential adverse effects, as stated by the American Academy of Otolaryngology 1