Antiphospholipid Syndrome Diagnosis Criteria

Laboratory Confirmation and Antibody Positivity

• Laboratory confirmation of positive antiphospholipid antibodies (lupus anticoagulant, anticardiolipin antibodies, or anti-β2-glycoprotein I antibodies) is mandatory, and must be confirmed at least 12 weeks apart to avoid transient positivity 1
• Patients positive for all three antibody types (LAC + aCL + aβ2GPI of same isotype) show the strongest association with obstetric APS and have the highest risk of recurrent pregnancy complications 1, 2, 3

Clinical Evaluation and Diagnosis

• The American College of Obstetricians and Gynecologists recommends considering testing for antiphospholipid antibodies in any patient with recurrent pregnancy morbidity, as pregnancy itself can trigger or unmask APS 1