Maximum Dose of Augmentin for Pediatric Patients

Standard Dosing Framework

The American Academy of Pediatrics recommends a high-dose formulation of 90 mg/kg/day of amoxicillin component divided into 2 doses for resistant pathogens, as seen in patients with common infections 1, 2
The standard-dose formulation is 45 mg/kg/day of amoxicillin component divided into 2 doses for less severe infections, according to the Infectious Diseases Society of America 1
The high-dose regimen specifically targets β-lactamase-producing Haemophilus influenzae and penicillin-resistant Streptococcus pneumoniae, as recommended by the Centers for Disease Control and Prevention 1, 2

For community-acquired pneumonia in pediatric patients with suspected resistant pathogens, the recommended dose is 90 mg/kg/day of amoxicillin component in 2 divided doses, as suggested by the American Thoracic Society 1, 2
This provides optimal coverage for β-lactamase-producing organisms, according to the National Institutes of Health 1

The absolute maximum limit for amoxicillin is 4000 mg/day, regardless of weight, as recommended by the Food and Drug Administration 2

The American Academy of Pediatrics recommends a standard dose of 90 mg/kg/day of amoxicillin-clavulanic acid divided into 2 doses for a 12-year-old child, with a maximum daily dose of 4 g of amoxicillin 3
Twice-daily dosing is preferred for convenience and comparable efficacy, with a dose of 45 mg/kg/day divided into 2 doses 4

For respiratory tract infections, such as pneumonia and sinusitis, high-dose amoxicillin-clavulanate at 90 mg/kg/day in 2 divided doses is recommended when resistant Streptococcus pneumoniae is suspected 3

The duration of therapy is typically 5-7 days for most infections, but may require longer courses for specific infections, such as complicated infections or osteomyelitis 3