Reconstituting Ceftriaxone with Lidocaine for Intramuscular Administration
Standard Reconstitution Practice
- The Centers for Disease Control and Prevention recommends reconstituting ceftriaxone with 1% lidocaine solution when administering intramuscularly to reduce injection pain 1
- Use 1% lidocaine (without epinephrine) as the diluent for intramuscular ceftriaxone administration, as recommended by the CDC 1
Important Safety Considerations
- The CDC advises against using lidocaine with epinephrine for reconstitution, and instead recommends using plain 1% lidocaine 1
- The CDC specifically notes that intravenous ceftriaxone should never be reconstituted with lidocaine, and this reconstitution method is only for intramuscular administration 1