Side Effects of Ofatumumab (Kesimpta) in Clinical Use

Common Adverse Events

• In clinical trials, the most frequently reported adverse events with ofatumumab included upper respiratory tract infections. 1
• Injection-related reactions with ofatumumab may include fever. 2

Specific Side Effects

• When used in conditions like chronic lymphocytic leukemia (CLL), ofatumumab's documented side effects include chills, diarrhea, flushing, and rash. 1
• Ofatumumab side effects in CLL patients also include bronchospasm, dyspnea, and pyrexia. 3

Monitoring Recommendations

• Regular monitoring of immunoglobulin levels during Kesimpta treatment is recommended, with particular attention to IgM and IgG levels. 2
• Low IgM levels can increase the risk of infections, particularly with encapsulated bacteria. 2