Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/22/2025

Management of Coxsackie Virus Infections

Introduction to Coxsackie Virus Infections

  • Coxsackie virus infections, also known as hand, foot, and mouth disease, are self-limited viral infections that resolve without antiviral treatment, and the American Academy of Pediatrics recommends focusing on symptomatic relief with oral analgesics, cold compresses, and maintaining hydration 1

Mechanism of Harm of Topical Steroids

  • Topical corticosteroid administration can lead to prolonged viral shedding in animal models of viral conjunctivitis, suggesting steroids may extend the infectious period, according to the American Academy of Ophthalmology 1

Appropriate Management of Coxsackie Sores

  • The American Academy of Pediatrics recommends avoiding any immunosuppressive therapies, including topical steroids, during the active viral phase of Coxsackie virus infections, and instead focusing on supportive care with oral analgesics, cold compresses, and maintaining hydration 1