Administration of Prolia

Dosing and Administration

• The standard dose of Prolia is 60 mg every 6 months for osteoporosis indications, as recommended by clinical guidelines 1
• For bone metastases from cancer, a higher dose of 120 mg monthly is used, which is a different indication than osteoporosis 2

Pre-Treatment Requirements

• Dental examination is recommended before starting Prolia therapy to minimize osteonecrosis of the jaw risk, according to the Journal of Clinical Oncology 3
• All patients must receive calcium and vitamin D supplementation throughout treatment, with some guidelines recommending higher supplementation doses 2

Supplementation Guidelines

• The American College of Clinical Guidelines recommends calcium 1000 mg daily and at least 400 IU vitamin D daily for all patients receiving Prolia 2