Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/28/2025

Premenstrual Dysphoric Disorder Diagnosis and Treatment

Understanding PMDD

  • PMDD is a severe form of premenstrual syndrome characterized by specific symptoms that occur during the luteal phase of the menstrual cycle, substantially interfering with daily activities, and resolving during menstruation or shortly after, as recognized by the American Psychiatric Association in the DSM-5 and the World Health Organization in the ICD-11 1
  • The World Health Organization and the American Psychiatric Association officially recognize PMDD as a distinct diagnostic entity, with symptoms including irritability and affect lability, in the ICD-11 and DSM-5, respectively 1

Treatment Approaches for PMDD

  • Cognitive Behavioral Therapy (CBT) shows positive results in reducing functional impairment, depressed mood, and anxiety in patients with PMDD, as reported by the Dialogues in Clinical Neuroscience 1