Antiemetic Therapy with Prochlorperazine

Efficacy and Safety

• Repeated doses of prochlorperazine can prolong QT interval and potentially precipitate torsades de pointes 1
• For patients with persistent nausea despite prochlorperazine, consider adding a serotonin antagonist such as ondansetron or granisetron 2
• For chemotherapy-induced nausea, a combination approach with dexamethasone may be more effective 3