Medications Similar to Trintellix (Vortioxetine)

Mechanism of Action and Clinical Effects

Vilazodone combines SSRI action with 5-HT1A receptor partial agonism, making it the most similar to Trintellix (vortioxetine) in terms of mechanism of action, according to the American College of Physicians 1
Desvenlafaxine is an SNRI with effects on both serotonin and norepinephrine systems, but lacks the receptor modulation of vortioxetine, as noted by the American Academy of Family Physicians 1, 2
Mirtazapine has a multimodal action but works primarily through different receptors (alpha-2 adrenergic), as reported by the American College of Physicians 3
Bupropion has a different mechanism (dopamine/norepinephrine) but may have cognitive benefits, according to the American College of Physicians 3

Fluoxetine has a long half-life but lacks the receptor modulation of vortioxetine, as noted by the American Academy of Family Physicians 2
Escitalopram has similar metabolism but is more selective for serotonin reuptake, according to the American Academy of Family Physicians 2
Vortioxetine has been shown to be as effective as desvenlafaxine for MDD treatment, as reported by the American College of Physicians 4

When selecting an alternative to vortioxetine, Vilazodone is the first choice if cognitive symptoms are prominent, due to its similar mechanism of action, as recommended by the American College of Physicians 1, 3
Vilazodone is also the first choice if sexual dysfunction is a concern, according to the American College of Physicians 3
Bupropion is an alternative if sexual dysfunction is a concern, as noted by the American College of Physicians 3