Sildenafil Dosing and Efficacy

Initial Dosing and Titration

• The American Urological Association recommends a starting dose of sildenafil of 50 mg taken approximately one hour before sexual activity, with a dose range of 25-100 mg based on efficacy and tolerability 1
• Dose can be adjusted based on efficacy and tolerability, and may be increased to 100 mg for improved efficacy if 50 mg is insufficient 1

Efficacy Considerations

• Approximately 69% of men report improved erections with sildenafil versus 35.5% with placebo, according to the American College of Physicians 2
• Dose-related improvements in erectile function have been observed, with 50 mg vs. 25 mg showing improved efficacy 2

Monitoring and Follow-up

• The American Urological Association recommends periodic follow-up to assess efficacy, side effects, and any significant changes in health status or medications 4, 1
• If initial treatment fails, evaluation of whether the trial was adequate is recommended before considering alternative treatments, as suggested by the American Urological Association 4