Mechanism of Kerecis Fish Skin Graft Breakdown in the Body

Breakdown Mechanism Through Inflammation Resolution

Omega-3 polyunsaturated fatty acids (PUFAs) in the fish skin serve as precursors for specialized pro-resolving mediators (SPMs) including resolvins, protectins, and maresins, which are involved in the breakdown process of Kerecis fish skin grafts, according to the American Heart Association 1, 2
These SPMs actively disrupt inflammatory pathways and shift the immune response toward resolution and homeostasis, facilitating proper tissue integration, as recommended by the American College of Critical Care Medicine 2
Unlike traditional anti-inflammatory agents, the SPMs from omega-3 PUFAs promote immune modulation and tissue repair without compromising host defenses, with a moderate level of evidence supporting this claim, as stated by the American College of Critical Care Medicine 2

More high-quality randomized controlled trials are needed to fully understand the comparative advantages of fish skin graft breakdown versus other dermal substitutes, with a low level of evidence currently available, as noted by the medical community, but not specifically by a guideline society, however an example of a society that may be involved is the American College of Surgeons 3