Safety of Xeloda and Tadalafil Co-administration

Medication Interactions

• The American Academy of Dermatology notes that tadalafil has known interactions with certain medications, including calcium channel blockers, statins, benzodiazepines, and other medications, but capecitabine is not among them 1
• The primary contraindication for tadalafil is concomitant use with nitrate medications, which can cause severe hypotension, as recommended by medical guidelines 2

Clinical Guidance

• Medical guidelines recommend that when prescribing tadalafil, ensure the patient is not taking nitrate medications before prescribing tadalafil, and assess cardiovascular risk status before prescribing tadalafil 2