Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 12/11/2025

Discontinuation of GLP-1 Receptor Agonists

Comparison with Other Medications

  • The Centers for Disease Control and Prevention recommends tapering protocols for opioids, benzodiazepines, and antipsychotics, which cause neuroadaptive changes requiring gradual dose reduction, in contrast to GLP-1 receptor agonists like semaglutide 1, 2, 3

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