Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 11/1/2025

Management of Scrotal Dryness and Itching Without Visible Lesions

Initial Treatment and Prevention

  • The Centers for Disease Control and Prevention recommends implementing preventive measures, such as wearing cotton underwear, avoiding irritants, and keeping the area dry, to prevent recurrence of scrotal dryness and itching 1

Diagnostic Considerations and Treatment Algorithm

  • The American College of Radiology suggests that scrotal ultrasound is not required for chronic dryness and itching without visible lesions, as it is not an acute surgical emergency 2, 3

Special Populations

  • The Centers for Disease Control and Prevention advises considering atypical fungal or mycobacterial causes in immunocompromised patients or those with HIV if standard treatment fails, and recommends preventive measures to prevent recurrence of scrotal dryness and itching 1, 4