Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/4/2025

Management of Nasal Epistaxis

Initial Management

  • The American Academy of Otolaryngology-Head and Neck Surgery recommends first-line treatment should focus on direct nasal compression for 10-15 minutes while sitting upright with the head slightly tilted forward, followed by application of topical vasoconstrictors if bleeding persists 1, 2
  • Position the patient sitting upright with head slightly tilted forward to prevent blood from entering the airway or stomach 2
  • Apply firm sustained compression to the lower third (soft part) of the nose for at least 10-15 minutes without checking if bleeding has stopped 3, 2

If Bleeding Persists After Initial Compression

  • Apply a topical vasoconstrictor such as oxymetazoline or phenylephrine spray (2 sprays in the bleeding nostril) 3, 2
  • This approach resolves 65-75% of epistaxis cases that don't stop with compression alone 2

Medication Considerations

  • No need to discontinue or adjust psychiatric medications for an isolated epistaxis episode 4
  • First-line treatments should be initiated before considering any medication adjustments 4, 3

Prevention of Recurrence

  • Once bleeding has stopped, apply hydrating or lubricating agents such as petroleum jelly to prevent recurrence 3, 2
  • Recommend regular use of saline nasal sprays to keep the nasal mucosa moist 3

When to Seek Further Medical Attention

  • If bleeding does not stop after 15 minutes of continuous pressure 3
  • If the patient experiences dizziness due to blood loss 3
  • If bleeding is severe (duration >30 minutes over a 24-hour period) 3
  • If the patient shows signs of hemodynamic instability such as tachycardia or hypotension 2

Advanced Treatment Options (if necessary)

  • If epistaxis persists despite initial measures, evaluation by an ENT specialist may be necessary 3
  • Options such as nasal cauterization, nasal packing, or in severe cases, arterial ligation may be considered 3, 2
  • Nasal endoscopy may be performed to examine the nasal cavity and nasopharynx when bleeding is difficult to control 2

REFERENCES

1

clinical practice guideline: nosebleed (epistaxis). [LINK]

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2020

2

Management of Frequent Nosebleeds (Epistaxis) [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

3

Management of Epistaxis in Patients on Ozempic (Semaglutide) [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

4

clinical practice guideline: nosebleed (epistaxis). [LINK]

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2020