Safety of Combining Trintellix (Vortioxetine) with Rexulti (Brexpiprazole)

Safety Profile of the Combination

• Neither medication has been specifically identified in major drug interaction guidelines as having contraindications when used together 1, 2, 3

Monitoring Recommendations

• Monitor for potential serotonergic effects when combining these medications, although the risk of serotonin syndrome is lower than with combinations of multiple strong serotonergic agents 4, 5

Potential Pitfalls and Precautions

• Although direct interaction between these two specific medications is not a major concern, be aware that adding other serotonergic medications to this combination could increase the risk of serotonin syndrome 4, 5
• Avoid adding MAOIs to this combination, as this would significantly increase the risk of serotonin syndrome 4