Time Intervals for Misoprostol in Second Trimester Abortions

Important Considerations and Cautions

• Misoprostol should be avoided in women with previous cesarean delivery due to the possibility of uterine rupture 1, 2, 3
• The American College of Obstetricians and Gynecologists (ACOG) notes that while the optimal dosage and timing interval of misoprostol are not definitively established, lower dosages (25 μg every three to six hours) are effective for cervical ripening and induction of labor 1