Wegovy Dosing and Titration

Standard Titration Schedule

The standard Wegovy titration schedule starts with 0.25mg once weekly for 4 weeks, followed by escalation to 0.5mg, 1.0mg, 1.7mg, and finally 2.4mg once weekly, which is the target maintenance dose for weight management, as recommended by clinical guidelines 1
The American College of Clinical Endocrinologists recommends a gradual titration schedule, such as the one described, to minimize gastrointestinal side effects while reaching the therapeutic dose 1

The FDA recommends gradual titration, allowing gastrointestinal tolerance to develop and minimizing adverse events like nausea and diarrhea, with a 16-week escalation schedule 1
Long-term use of semaglutide is necessary, as participants who discontinued the medication regained significant weight, indicating lifelong treatment may be required, according to the American Heart Association 2
If doses are missed, it is recommended to consider restarting the titration schedule rather than jumping directly to 2.4mg, especially if 3 or more consecutive doses are missed at the 1.7mg level, as suggested by clinical guidelines 3