Risk Factors for Silent Miscarriage

Biological and Physiological Factors

• Women with diminished ovarian reserve, characterized by low anti-Müllerian hormone (AMH) levels, have approximately 35% increased relative risk of silent miscarriage compared to those with normal ovarian reserve 1
• Diminished ovarian reserve, as measured by low AMH levels, increases miscarriage risk by approximately 35% (OR 1.35; 95% CI, 1.10-1.66) 2, 1

Medical Conditions

• The American College of Obstetricians and Gynecologists notes that pre-existing medical conditions, particularly cardiovascular disease, can increase risk of pregnancy complications including miscarriage 3
• Chronic health conditions that are part of the obstetrical comorbidity index (OB-CMI) including hypertension contribute to increased risk of adverse pregnancy outcomes 4, 5

Risk Factors for Silent Miscarriage

Demographic Factors

• Advanced maternal age significantly increases risk for pregnancy-related complications including silent miscarriage; nearly one-third of all pregnancy-related deaths occur in women aged 35 years or older 6