Management of Chlorpyrifos Poisoning

Pathophysiology and Toxicity

• Chlorpyrifos causes irreversible acetylcholinesterase inhibition, leading to cholinergic syndrome through acetylcholine accumulation, with toxicity extending beyond simple cholinesterase inhibition to include neuroinflammation and disruption of multiple neurotransmitter systems 1, 2, 3, 4, 5