Concurrent Use of Phentermine and Adderall

Pharmacological Concerns

• The combination of phentermine and Adderall can lead to additive stimulant effects, potentially causing dangerous increases in blood pressure, heart rate, and risk of cardiovascular events, as warned by the American Diabetes Association 1
• Phentermine is contraindicated for use in combination with monoamine oxidase inhibitors and other sympathomimetic amines, which would include Adderall, according to the American Diabetes Association 1

Cardiovascular Risks

• Combined use of phentermine and Adderall may significantly increase the risk of cardiac arrhythmias, as reported by the American Gastroenterological Association 2

Neurological and Psychiatric Risks

• Concurrent use of phentermine and Adderall can lead to insomnia, as reported by the American Gastroenterological Association 2

Special Considerations

• Women of reproductive potential should be counseled about the risks of using phentermine and Adderall together, as both medications are contraindicated in pregnancy, according to the American College of Obstetricians and Gynecologists and the American Diabetes Association 1, 3

Alternative Approaches

• For ADHD in adults who need weight management, consider non-stimulant ADHD medications like bupropion, as suggested by the American College of Obstetricians and Gynecologists 3
• For weight management in adults with ADHD, consider non-stimulant weight loss medications like orlistat, naltrexone/bupropion, liraglutide, or semaglutide, as recommended by the American Diabetes Association and the American Gastroenterological Association 1, 2, 5