Hangover Effects of Quetiapine Formulations

Pharmacokinetic and Clinical Implications

• Quetiapine is known to be sedating regardless of formulation, but the XR formulation's pharmacokinetic profile helps reduce the severity of morning sedation 1
• Guidelines recognize quetiapine's sedating properties and recommend dose adjustments in older patients and those with hepatic impairment for both formulations 1, 2

Special Populations and Adverse Effects

• Both formulations require dose reduction in older patients and those with hepatic impairment due to risk of increased sedation 1, 2
• Morning hangover effects with either formulation may include orthostatic hypotension and dizziness, which can increase fall risk, particularly in older adults 1