Treatment Recommendations for Yeast Infections

Medication Options and Dosing by Infection Type

The American College of Obstetricians and Gynecologists recommends fluconazole 150 mg as a single oral dose for uncomplicated vulvovaginal candidiasis, with alternative options including topical antifungal agents for 1-7 days, according to the Infectious Diseases Society of America 2
For severe acute vulvovaginal candidiasis, the Infectious Diseases Society of America recommends fluconazole 150 mg every 72 hours for 2-3 doses total 2
The Infectious Diseases Society of America recommends initial induction with 10-14 days of topical agent or oral fluconazole, followed by maintenance therapy with fluconazole 150 mg weekly for 6 months for recurrent vulvovaginal candidiasis 2
For mild oropharyngeal candidiasis, the Infectious Diseases Society of America recommends clotrimazole troches 10 mg 5 times daily for 7-14 days, miconazole mucoadhesive buccal 50-mg tablet applied once daily for 7-14 days, or nystatin suspension 4-6 mL 4 times daily for 7-14 days 2
For moderate to severe oropharyngeal candidiasis, the Infectious Diseases Society of America recommends fluconazole 200 mg on the first day, followed by 100 mg daily for 7-14 days 2
For symptomatic urinary tract candidiasis, the Infectious Diseases Society of America recommends fluconazole 200 mg daily for 2 weeks 3
For pyelonephritis, the Infectious Diseases Society of America recommends fluconazole 200-400 mg daily for 2 weeks 4

For denture-related candidiasis, the Infectious Diseases Society of America strongly recommends disinfection of dentures in addition to antifungal therapy 2
For fluconazole-resistant infections, the Infectious Diseases Society of America recommends alternative treatments, including AmB deoxycholate 0.3-0.6 mg/kg daily for 1-7 days with or without oral flucytosine for C. glabrata, and AmB deoxycholate 0.3-0.6 mg/kg daily for 1-7 days for C. krusei 4

The Infectious Diseases Society of America emphasizes the importance of addressing underlying factors, such as disinfecting dentures in denture-related candidiasis, to prevent treatment failure 2
The American College of Obstetricians and Gynecologists recommends confirming diagnosis with clinical examination and wet mount/KOH preparation before initiating treatment, according to the Infectious Diseases Society of America 1