Ceftriaxone Administration Guidelines

Adult Dosing Guidelines

The standard adult daily dose of intramuscular ceftriaxone is 1-2 grams given once daily, depending on infection type and severity 1
For uncomplicated gonococcal infections, a single intramuscular dose of 250mg is sufficient 1
For disseminated gonococcal infection (DGI), ceftriaxone 1 gram IM every 24 hours is recommended, continuing for 24-48 hours after improvement begins 1
For severe infections such as bacterial meningitis, higher and more frequent dosing may be required (2 grams every 12 hours) 1
For ceftriaxone-resistant strains, higher doses and twice-daily dosing may be required 1
Treatment failures have been reported with lower doses (250-500 mg), particularly for pharyngeal infections 1

For neonates: postnatal age ≤7 days, 50 mg/kg/day given every 24 hours; postnatal age >7 days and ≤2000 g, 50 mg/kg/day given every 24 hours; postnatal age >7 days and >2000 g, 50–75 mg/kg/day given every 24 hours 2
For infants and children: 50–75 mg/kg/day divided every 12–24 hours 2
Should not be used in hyperbilirubinemic neonates 2