Tacrolimus-Induced Pancreatitis: Monitoring and Management

Monitoring of Tacrolimus Blood Levels

• Regular monitoring of tacrolimus blood levels is essential to prevent toxicity, as recommended by the American Thoracic Society, and extremely high concentrations may increase the risk of pancreatitis 1
• Monitoring serum potassium, glucose levels, renal function, and hepatic function may help detect tacrolimus-induced abnormalities early, according to the American College of Chest Physicians 2

Prevention and Screening

• Routine monitoring of pancreatic enzymes in asymptomatic patients is not recommended, as stated by the American Society of Clinical Oncology 3