Treatment of Reactive Arthritis

Initial Management

• NSAIDs should be used at the minimum effective dose for the shortest time possible after evaluation of gastrointestinal, renal, and cardiovascular risks 1
• Intra-articular glucocorticoid injections should be considered for relief of local symptoms of inflammation 1

Severe or Refractory Cases

• Methotrexate is considered the anchor drug for persistent inflammatory arthritis unless contraindicated 1

Monitoring and Follow-up

• Disease activity should be assessed at 1-3 month intervals until treatment target has been reached 1
• Monitoring should include tender and swollen joint counts, patient and physician global assessments, ESR and CRP 1

Non-pharmacological Interventions

• Dynamic exercises and occupational therapy should be considered as adjuncts to drug treatment 1
• Patient education about the disease, its outcome, and treatment is important 1
• Education programs aimed at coping with pain, disability, maintenance of ability to work, and social participation may be used as adjunct interventions 1