Digoxin and Hypotension

Adverse Effects of Digoxin

The American Heart Association and American College of Cardiology recommend monitoring for gastrointestinal symptoms, such as anorexia, nausea, and vomiting, as common adverse effects of digoxin 1, 2
The European Society of Cardiology notes that neurological effects, including dizziness, blurred vision, and headache, are associated with digoxin use 3
Cardiac arrhythmias, particularly with toxicity, are a documented adverse effect of digoxin, according to the American College of Cardiology and European Heart Journal 2, 3
Visual disturbances are also a recognized adverse effect of digoxin, as reported by the American Heart Association and American College of Cardiology 1, 2

The American Heart Association states that beta-blockers, such as esmolol, metoprolol, and propranolol, can cause hypotension as a well-documented side effect 1, 4
The American College of Cardiology notes that calcium channel blockers, including diltiazem and verapamil, commonly cause hypotension 1, 2
The American Heart Association reports that amiodarone can cause hypotension, especially with intravenous administration 1, 5

The American College of Cardiology recommends monitoring patients on digoxin for signs of toxicity, such as nausea, visual changes, and arrhythmias, rather than hypotension 1, 2
The European Heart Journal advises adjusting digoxin dosing based on renal function, as digoxin is primarily eliminated by the kidneys 2, 3
The American Heart Association warns that drug interactions, particularly with amiodarone, verapamil, and other P-glycoprotein inhibitors, can increase digoxin levels 1, 2