Management of Paget's Disease of Bone with Bisphosphonates

First-Line Treatment: Bisphosphonates

• Pamidronate has sustained effects for months following a single injection in patients with Paget's disease, as reported by the American Journal of Kidney Diseases 1
• Risedronate is effective for Paget's disease but is contraindicated in patients with a glomerular filtration rate (GFR) less than 30 ml/min/1.73 m², according to the American Journal of Kidney Diseases 2

Treatment Approach

• For patients with renal impairment, dose adjustments or alternative agents may be needed based on GFR, and alendronate is not recommended in patients with GFR less than 35 ml/min/1.73 m², as suggested by the American Journal of Kidney Diseases 2