Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/28/2025

Safety Precautions for Transdermal Medications During MRI

Risks Associated with Transdermal Medications

  • Transdermal medication patches like Minitran may contain conductive materials that can heat up during MRI scanning, potentially causing severe and rapid burns 2
  • Radiofrequency fields used in MRI can create localized heating when in contact with any conductive material left on the patient's skin 2, 3
  • The MRI's powerful radio transmitter interacts with patient tissue and any conductive materials at the resonant frequency of the scanner, leading to power dissipation and temperature increase 4

Required Safety Protocol

  • All patients must be thoroughly screened for devices, implants, and medication patches before entering the MRI environment 3
  • Minitran plasters should be removed and the skin area cleaned before the MRI procedure 2
  • The removal should be documented as part of the MRI safety screening process 3
  • After the MRI is completed, a new Minitran plaster can be applied according to the original prescription schedule 3

MRI Safety Classification System

  • All equipment and implants for MRI use fall into three formal categories MR Safe: contains no material that would present a hazard at any field 3
    • MR Conditional: safe to scan under specified conditions detailed by the manufacturer 3
    • MR Unsafe: presents an unacceptable risk to patients or staff if used within the MR environment 3
  • Transdermal medication patches with conductive components are typically considered MR Unsafe due to the risk of RF heating 2, 3

Additional Safety Considerations

  • All staff and patients must be screened for ferromagnetic materials before entering the MRI suite 4
  • Special MRI-compatible monitoring equipment must be used if the patient requires monitoring during the procedure 5, 6
  • Careful documentation of the removal and subsequent reapplication of the Minitran plaster should be maintained to ensure continuity of treatment 3
  • The MRI department's MR Responsible Person and MR Safety Expert should be consulted regarding any questions about medication patches and MRI safety 3

Clinical Implications

  • Temporary discontinuation of nitroglycerin delivery during the MRI procedure is generally well-tolerated for most patients 3
  • For patients with unstable angina or those highly dependent on continuous nitroglycerin therapy, the timing of the MRI should be carefully planned, and alternative short-acting nitroglycerin formulations should be available if needed 3
  • The clinical team should weigh the risks of temporary discontinuation against the risks of potential thermal injury 2, 3