Omega-3 Supplementation During Pregnancy with Low-Dose Aspirin

Safety of Combined Use

Low-dose aspirin (81-100mg daily) used during IVF and early pregnancy does not contraindicate omega-3 fatty acid supplementation, according to the American College of Chest Physicians 1
Maternal aspirin ingestion is associated with excretion of salicylates into breast milk, but low-dose aspirin (<100mg/day) has not been shown to have significant effects on neonatal platelet function, as reported by the American College of Chest Physicians 1
For lactating women using low-dose aspirin for vascular indications who wish to breastfeed, guidelines suggest continuing this medication (Grade 2C recommendation) from the American College of Chest Physicians 1

Low-dose aspirin (50-100 mg/day) is recommended throughout pregnancy for women at risk of preeclampsia, according to the American College of Rheumatology 2

If delivery is planned, aspirin should be discontinued one week prior to surgical procedures (including delivery) and restarted 24 hours after surgery when bleeding risk is acceptable, as suggested by the National Comprehensive Cancer Network 3
For women at high risk of preeclampsia, low-dose aspirin should be started in the first trimester, according to the American College of Rheumatology 2
In cases of high-risk pregnancy, consider continuing low-dose aspirin throughout pregnancy and for six weeks postpartum, as recommended by the National Comprehensive Cancer Network 3

Low-dose aspirin (81-100mg daily) is the standard dose used during pregnancy, according to the American College of Rheumatology 2

Aspirin should be discontinued 1-2 weeks prior to delivery to reduce bleeding risk, as suggested by the National Comprehensive Cancer Network and the European Association for the Study of the Liver 3, 4
High-dose aspirin (several grams per day) should be avoided as it has been associated with metabolic acidosis in breastfed infants, according to the American College of Chest Physicians 1
Monitor for any signs of bleeding, though studies show no increased risk of postpartum hemorrhage with low-dose aspirin use, as reported by the American College of Physicians 5, 6