Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 10/30/2025

Epidural Steroid Injections for Radiculopathy

Indications and Contraindications

  • The Spine Intervention Society's appropriate use criteria explicitly state that repeat injection with steroid is appropriate only if there was at least 50% relief for at least 2 months after the first injection 1
  • The American Society of Anesthesiologists requires additional therapeutic injections should only be performed if the initial injection resulted in at least 50% pain relief for at least 2 weeks 1
  • The American Academy of Neurology explicitly recommends against epidural steroid injections for non-radicular low back pain 1

Diagnostic Criteria

  • The American College of Physicians defines radicular pain as pain and/or numbness that radiates below the knee, which this patient demonstrates 1
  • Clinical signs of radiculopathy including decreased sensation in the lower extremities support the diagnosis 1
  • MRI demonstrates multilevel lumbar spondylosis, disc protrusion, and lumbar stenosis providing the required anatomic substrate for intervention 1

Treatment Guidelines

  • The American Society of Anesthesiologists strongly recommends epidural steroid injections with or without local anesthetics for patients with radicular pain or radiculopathy as part of a multimodal treatment regimen 1
  • Epidural steroid injections should be provided as part of a comprehensive pain management program that includes physical therapy, patient education, psychosocial support, and oral medications 1
  • The American College of Physicians strongly recommends MRI evidence of pathology such as nerve root compression to be considered for lumbar epidural steroid injection 1

Procedural Requirements

  • Fluoroscopic guidance must be used for epidural injections to ensure proper needle placement and reduce risk of complications 1
  • The American Society of Anesthesiologists strongly agrees that image guidance (fluoroscopy) should be used for both interlaminar and transforaminal epidural injections 1
  • The patient must be counseled about potential complications including dural puncture, insertion-site infections, sensorimotor deficits, cauda equina syndrome, discitis, epidural granuloma, and retinal complications 1

Special Considerations

  • Epidural injections are not recommended for long-term maintenance treatment of chronic low-back pain without clear radiculopathy 2
  • The use of lumbar epidural injections is recommended as a treatment option to provide temporary, symptomatic relief in selected patients 2