Clonazepam Pharmacokinetics and Metabolism

Pharmacokinetic Properties

• The American Academy of Sleep Medicine notes that the elimination half-life of clonazepam is typically 30 to 40 hours, making it a long-acting benzodiazepine 1
• The long half-life (30-40 hours) means steady-state is not reached for approximately 5-7 days, and drug accumulation can occur with repeated dosing 1