Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 11/9/2025

Pharmacotherapy for Somatic Symptom Disorder

Medication Considerations

  • Standard antidepressant doses are appropriate for somatic symptom disorder, in contrast to OCD which requires higher SSRI doses, according to the Nature Reviews Disease Primers 1
  • Monitor for serotonin syndrome when using serotonergic agents, particularly if combining medications, as recommended by Praxis Medical Insights: Practical Summaries of Clinical Guidelines 2

REFERENCES

1

obsessive-compulsive disorder. [LINK]

Nature Reviews Disease Primers, 2019

2

Treatment of Treatment-Resistant OCD [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025