Aripiprazole Dosing Guidelines for Adults with Schizophrenia

Assessment and Treatment Duration

• The American Psychiatric Association recommends assessing efficacy after 4 weeks at a therapeutic dose with documented good adherence before considering switching to another antipsychotic 1, 2
• Treatment failure should not be assessed before 4 weeks at a therapeutic dose with confirmed adherence 1, 2

Special Clinical Considerations

• For negative symptoms, aripiprazole is a suitable option when switching antipsychotics, with a recommended starting dose of 10-15 mg/day 2
• Aripiprazole can be added to clozapine for augmentation when significant positive symptoms persist, with no specified different starting dose for augmentation 1, 2