Aripiprazole Dosing Considerations for Special Populations
Dosing Adjustments for Older Patients and Those with Hepatic Impairment
- The American Society of Clinical Oncology recommends using lower starting doses in older patients and those with hepatic impairment, considering starting at 5 mg daily in these populations 1, 2
- The European Association for Clinical Pharmacology and Therapeutics suggests reducing the dose in poor metabolizers of CYP2D6, and reducing the dose by 50% when coadministered with CYP3A4 or CYP2D6 inhibitors 1, 2