Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/25/2025

Optimal Management of Esophageal Leiomyoma

Understanding Esophageal Leiomyoma

  • Leiomyomas are benign tumors and account for approximately two-thirds of all spindle cell tumors of the esophagus 1
  • Histologic evaluation is necessary to differentiate leiomyoma from GIST (gastrointestinal stromal tumor) 1
  • Tissue sampling using fine needle aspiration (FNA) or fine needle biopsy (FNB) can be useful to confirm diagnosis 1

Treatment Approach

  • More extensive resections (Ivor-Lewis, transhiatal, or segmental) are unnecessarily invasive for benign disease 2