Kortikosteroid Oral Dosis dan Penggunaan

Dosis Berdasarkan Kondisi Spesifik

The American Gastroenterological Association recommends a standard dose of 40-60 mg/day of prednisone for induction of remission in moderate to severe ulcerative colitis, with no additional benefit seen with doses higher than 60 mg/day 1
For children with nephrotic syndrome, the initial dose is 60 mg/m² or 2 mg/kg/day (maximum 60 mg/day) as a single dose for 4-6 weeks, followed by a maintenance phase of 40 mg/m² or 1.5 mg/kg on alternate days (maximum 40 mg on alternate days) for 2-5 months with tapering 2, 3
The British Association of Dermatologists recommends a dose of 0.75-1 mg/kg/day (approximately 50-80 mg/day for the average adult) for severe pemphigoid bullosa 5

The American College of Rheumatology classifies doses as low (<7.5 mg/day), medium (7.5-30 mg/day), and high (>30 mg/day) for rheumatic diseases 6

Patients on long-term steroid therapy should receive calcium and vitamin D supplementation, and undergo DEXA bone scans at 1-2 year intervals 4
The American Academy of Pediatrics recommends that children with significant weight excess have their dose based on ideal body weight 6
The risk of adrenal suppression is anticipated in patients receiving >7.5 mg/day for >3 weeks, and stress dosing is required for patients on medium to high dose chronic therapy 6

The American Gastroenterological Association does not recommend oral corticosteroids for maintenance therapy of ulcerative colitis due to lack of efficacy and significant side effects 1
Long-term use is associated with increased risk of serious infections and mortality 1
Doses >30 mg/day are associated with significant mortality in pemphigoid bullosa 5