Glimepiride Administration Guidelines

Special Considerations for Fasting Patients

For patients who fast, such as during Ramadan, glimepiride should be taken at the main meal of the day, as recommended by the American Diabetes Association 1, 2
For patients on once-daily dosing during fasting periods, the dose should be given before the sunset meal (Iftar), according to the American Diabetes Association 3
For patients on twice-daily dosing who are fasting, use half the usual morning dose at the predawn meal (Suhur) and the full dose at the sunset meal (Iftar), as suggested by the American Diabetes Association 3

For patients who exercise, taking glimepiride with food is particularly important as physical activity can increase the risk of hypoglycemia, as noted by the American Diabetes Association 4
Patients using insulin secretagogues like glimepiride may need to supplement with carbohydrates before exercise to prevent hypoglycemia, according to the American Diabetes Association 4