Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/23/2025

Treatment Options for Erectile Dysfunction After NSTEMI

Safety Considerations for ED Treatment Post-NSTEMI

  • The American College of Cardiology recommends that PDE5 inhibitors must not be administered to patients who have received nitrates within the past 24-48 hours, due to potentially dangerous hypotensive effects 1, 2
  • Nitroglycerin should not be administered to patients who have taken sildenafil within 24 hours or tadalafil within 48 hours, as recommended by the American College of Cardiology 1

Follow-Up Care

  • The American Heart Association, as published in Circulation, suggests that detailed discharge instructions should include education on medications and exercise, and that low-risk patients should follow up in 2-6 weeks, while higher-risk patients should return within 14 days 3
  • Patients should be instructed on what to do if they experience chest pain during sexual activity, according to the American Heart Association, as published in Circulation 4
  • If angina occurs during sexual activity, patients should immediately stop, rest, and use prescribed protocols for angina management, as recommended by the American Heart Association, as published in Circulation 4