Management of Hypertension with Loratadine

Safety and Recommendations

• The American College of Cardiology/American Heart Association (ACC/AHA) guidelines do not list loratadine as a medication that may cause elevated blood pressure or impair blood pressure control in patients with hypertension 1
• Antihistamines like loratadine are not identified as concerning for patients with hypertension, unlike decongestants, according to the American College of Cardiology and Circulation guidelines 2, 3
• Decongestants, such as pseudoephedrine and phenylephrine, can raise blood pressure and should be avoided in patients with hypertension, as recommended by the American College of Cardiology 1
• The American College of Cardiology recommends avoiding NSAIDs, such as ibuprofen and naproxen, as they can worsen blood pressure control in patients with hypertension 1
• Certain antidepressants, such as MAOIs, SNRIs, and TCAs, may elevate blood pressure and should be used with caution in patients with hypertension, according to the American College of Cardiology 1
• Oral contraceptives, particularly in uncontrolled hypertension, and systemic corticosteroids can raise blood pressure, as noted by the American College of Cardiology 1
• The European Heart Journal recommends monitoring blood pressure regularly to ensure it remains controlled in patients with hypertension 4
• Lifestyle modifications, including limiting alcohol, reducing sodium intake, increasing physical activity, and maintaining a healthy weight, are recommended for managing hypertension by the European Heart Journal and Hypertension 4, 5
• The European Heart Journal suggests taking prescribed antihypertensive medications as directed and targeting a blood pressure of 120-129 mmHg systolic for most adults 4
• The American College of Cardiology advises consulting a healthcare provider before combining multiple medications, especially in patients with hypertension 1
• Patients with hypertension should inform their healthcare provider about all medications they are taking, including over-the-counter products like loratadine, as recommended by the American College of Cardiology 1